4 Supplements That Might Be Making Your Inflammation Worse

Supplements often promise quick health fixes—but some could be making things worse, especially when it comes to inflammation. According to a recent EatingWell article by Amy Brownstein, M.S., RDN, a few popular supplements may actually increase inflammation levels in the body, rather than help reduce them.

First on the list is kava, a plant-based supplement used for relaxation. While it has cultural roots in traditional Pacific Island medicine, modern use has been linked to liver issues and increased inflammation. Some studies suggest that while kava might have anti-inflammatory effects, it can also trigger the release of harmful inflammatory molecules when taken in large or long-term doses.

High-dose iron supplements are another red flag. While iron is crucial for health, too much—especially above the safe upper limit of 40mg per day—can cause gastrointestinal issues and raise inflammation markers. Always get tested before supplementing with iron.

Conjugated linoleic acid (CLA), a supplement often marketed for weight loss, is an omega-6 fatty acid that might raise C-reactive protein (CRP) levels, a key inflammation marker. Though results are mixed, the risk is worth considering if you’re trying to manage inflammation naturally.

Lastly, vitamin A is essential, but supplements that exceed 3,000 micrograms daily could push CRP levels up. The body stores excess vitamin A in fat, and over time, this can lead to more harm than good.

Instead of loading up on pills, Brownstein and other dietitians recommend a simpler, food-first approach: move more, eat plant-rich meals, and manage stress.

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