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Experts Call on NIH to Prioritize Human-Centered Research

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On November 18, a coalition of 338 physicians, scientists, and advocates partnered with the nonprofit Physicians Committee for Responsible Medicine to urge the National Institutes of Health (NIH) to adopt a human-centered approach in its upcoming NIH-Wide Strategic Plan for 2026-2030. Their letter, addressed to NIH Director Monica M. Bertagnolli, MD, emphasized the need to shift research priorities toward methods that directly benefit patients and reduce reliance on animal testing.

Federal law requires the NIH to regularly update its strategic plan to guide biomedical research, foster collaboration, and drive advancements in health science. The coalition outlined specific recommendations, including increased funding and representation for human-specific research, inclusion of experts in human-based approaches on planning committees, and greater transparency in tracking the use of animal and human models in funded projects.

The letter also commended the NIH for its recent steps toward embracing alternatives to animal testing. Earlier in 2024, Dr. Bertagnolli accepted an advisory group’s recommendations to expand the use of innovative methods such as tissue chips and computational models. These technologies, which simulate human biology using cells, tissue, and data, offer more precise insights into human health and disease while reducing costs and timelines for research.

Signatories highlighted the transformative potential of these approaches, citing a report from the Advisory Committee to the Director Novel Alternative Methods working group: “human-specific methods ‘offer tremendous promise for helping us better understand fundamental biology to advance human health.”

Catharine E. Krebs, PhD, medical research program manager at the Physicians Committee, underscored the importance of this transition. “The NIH is making great strides in moving away from animal experiments toward human-centered methods that better model human biology and disease,” she said. She added that the upcoming strategic plan is a pivotal chance to formalize this progress and drive continued innovation in medical research.

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