New Study Links Antidepressant Use to Higher Risk of Sudden Cardiac Death

A new study presented at the European Heart Rhythm Association’s 2025 Congress has found a troubling connection between antidepressant use and sudden cardiac death. According to Ani Freedman reporting for Fortune, long-term antidepressant use—particularly over several years—may significantly raise the risk of fatal heart issues.

The study examined data from Danish adults who died in 2010, comparing sudden cardiac deaths among those who used antidepressants with those who didn’t. The findings showed a clear trend: individuals who had been on antidepressants for one to five years were 56% more likely to die from sudden cardiac arrest. That risk jumped to 2.2 times higher for those who had been taking them for six years or more.

The study covered a wide age range, and while young adults (18–29) didn’t show a significant increase in risk, older age groups did. For example, people aged 30–39 were five times more likely to suffer sudden cardiac death after six years of antidepressant use. Researchers didn’t single out specific drugs but noted that several classes, including SSRIs like Zoloft and Prozac, were involved.

The researchers suggested that both the medications and depression itself—known to be linked with poor heart health—may contribute to the risk. Lifestyle factors tied to depression, like reduced physical activity or delayed medical care, may also play a role.

For anyone concerned about mental health and its treatment, it’s a reminder to approach healing holistically—considering diet, lifestyle, and emotional well-being alongside medical options. A plant-based diet, regular movement, and supportive community can go a long way in boosting both mental and physical health.

Let’s rethink the way we approach mental health—less pharma, more plant-based. Advocate for natural healing, for yourself and the planet.

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